Monthly Archives: January 2016

To Know medical terms Homeopathic and NanoPharmacology

homeopathy-nanomedicine

Has the reader heard the term Nano Homeopathic and Pharmacology, in this article will discuss both, the information retrieved from the site www.homeopathic.com. May be useful

By Dana Ullman MPH

Nanotechnology

Western science has been marching towards the discovery of increasingly smaller particles of matter for the past centuries, from molecules and atoms to sub-atomic particles and quarks.

Likewise, the evolution of technology has witnessed the miniaturisation of devices along with their increased capabilities. “Nanotechnology” has become the popular term to refer to the study and manufacture of devices of molecular dimensions, of the range of nanometers or one-billionth of a meter.

Dr. Neal Lane, former director of the US National Science Foundation (NSF) said, “If I were asked for an area of science and engineering that will most likely produce the breakthrough of tomorrow, I would point to nanoscale science and engineering.”

A 1999 report from NSF Technology Council predicted that nanotechnology’s impact on the health, wealth, and security of the world’s population is expected to be “at least as significant as the combined influences of antibiotics, the integrated circuit, and human-made polymers”.

So far, research and development in nanotechnology in medicine have been limited to devices that monitor or replace biochemical processes in the body. But as yet, conventional scientists and physicians have not considered using nanopharmacological doses of medicinal agents.

Our conventional medical paradigm has tended to assume that increasingly large doses of pharmacological agents will create increasingly significant biological effects, even when it is well recognized that large doses of pharmacological agents do not necessarily lead to better or improved health.

In fact, increasing doses of most drugs generally lead to increased side effects. Most drugs have primarily been developed to replace, suppress, minimize, or interfere with specific biochemical function, while the discovery of pharmaceutical medicines to augment a person’s own immune and defence system has been an elusive and usually ignored goal.

Ironically, the few pharmacological agents that have been used in conventional medicine today that do something to augment a persons immune system are immunization and allergy treatments, both of which are based on an ancient (and modern) pharmacological principle of “similars.” (Although there are obvious similarities between these conventional medical treatments and homeopathic medicines, there are also significant differences, including: the homeopathic medicines are considerably smaller in dose and are individualized to the person’s total syndrome of symptoms, not simply to a localized or defined disease.) This concept of similars, that is, of using a medicinal agent in small doses based on what it causes in larger, toxic doses, represents the underlying principle of homeopathic medicine.

Largely as a result of the AIDS epidemic, it has made sense to seek to discover drugs that strengthen a person’s immune and defence system rather than seek to minimize the various individual symptoms that a person experiences. However, most physicians and scientists lack a conceptual framework for pharmacological agents that have this effect. And sadly, most are also ignorant and disdainful of homeopathy, which they commonly but incorrectly assume, uses such small doses that the medicines cannot have any biochemical let alone clinical effect.

Nanopharmacology and Homeopathy

While this skepticism of the efficacy of small doses of medicine is understandable from a strictly rational perspective, it ignores the large body of evidence from basic science, controlled clinical studies, epidemiological data, clinical outcomes trials, and historical review of the field.

Before discussing this evidence, it is useful to understand that homeopaths are the first to recognize that their medicines will not have any biological effect or clinical result unless the complex of symptoms that the sick person experiences are similar to the complex of symptoms that the medicine has been found to cause when given in toxic doses. It is not as though small doses of simply any medicine will elicit therapeutic results; such small doses can and will only initiate a healing response when a person is hypersensitive to a specific medicine.

Basic principles of physics teach us that hypersensitivity exists when there is resonance. Homeopathy is itself based on resonance (commonly referred to as the “principle of similars”). Even the word “homeopathy” is derived from two Greek words, “homoios” which means similar, and “pathos” which means suffering or disease.

Typically, homeopaths engage patients in a detailed interview to elicit the various physical, emotional, and mental symptoms that the sick person is experiencing. Homeopaths seek to find a medicinal agent that has the capacity to cause in healthy people the similar symptoms that the sick patient is experiencing. Rather than treating localized symptoms or a specific disease, homeopaths treat syndrome complexes, of which the symptoms and the disease are a part. Once a conventional medical diagnosis is determined, the homeopath then seeks to find the symptoms that are unique to the patient, and then, a homeopathic medicine is individualized to each patient’s symptom complex.

Homeopathic Medicine: A Nanopharmacology

Homeopathic medicine presents a significantly different pharmacological approach to treating sick people. Instead of using strong and powerful doses of medicinal agents that have a broad-spectrum effect on a wide variety of people with a similar disease, homeopaths use extremely small doses of medicinal substances that are highly individualized to a person’s physical and psychological syndrome of disease, not simply an assumed localized pathology.

Homeopathic medicines are so small in dose that it is appropriate to refer to them as a part of a newly defined field of nanopharmacology. To understand the nature and the degree of homeopathy’s nanopharmacology, it is important to know the following characteristics of how homeopathic medicines are made.

Most homeopathic medicines are made by diluting a medicinal substance in a double-distilled water. It should be noted that physicists who study the properties of water commonly acknowledge that water has many mysterious properties. Because homeopaths use a double-distilled water, it is highly purified, enabling the medicinal substance to solely infiltrate the water. The medicinal solution is usually preserved in an 87% water/alcohol solution. Each substance is diluted, most commonly, 1 part of the original medicinal agent to 9 or 99 parts double-distilled water. The mixture is then vigorously stirred or shaken. The solution is then diluted again 1:9 or 1:99 and vigorously stirred. This process of diluting and stirring is repeated 3, 6, 12, 30, 200, 1,000, or even 1,000,000 times.

It is inaccurate to say that homeopathic medicines are just extremely diluted; they are extremely “potentized.” Potentization refers to the specific process of sequential dilution with vigorous stirring. The theory is that each consecutive dilution in conjunction with the process of shaking/stirring infiltrates the new double-distilled water and imprints upon it the fractal form of the original substance used (fractal refers to the specific consecutively smaller pattern or form within a larger pattern).

Some highly respected basic scientific research has begun to verify the claims that homeopaths have made for 200 years, and that various extremely low concentrations of biological agents can exhibit powerful biochemical effects. Beta-endorphins are known to modulate natural killer cell activity in dilutions of 10-18. Interleukin-1, an important agent in our immune system, has been found to increase T-cell clone proliferation at 10-19. And pheromones, which are externally emitted hormones that various animals and insects are known to create, will result in hypersensitive reaction when as little as a single molecule is received (scientists have no way at present to assess the effects of less than a molecule).

It is commonly observed that organisms experience a biphasic response to various chemicals, that is, extremely small doses of a substance exhibit different and sometimes opposite effects than what they cause in high concentrations. For instance, it is widely recognized that normal medical doses of atropine block the parasympathetic nerves, causing mucous membranes to dry up, while exceedingly small doses of atropine causes increased secretions to mucous membranes.

In fact, many medical and scientific dictionaries refer to “hormesis” or “the Arndt-Schulz law” (listed under “law”) as the observations that weak concentrations of biological agents stimulate physiological activity, medium concentrations of agents depress physiological activity, and large concentrations halt physiological activity.

There is also a significant body of research on hormesis (hundreds of studies) conducted by conventional scientists, none of whom even mention homeopathy. The journal, Health Physics devoted an entire issue to this subject in May, 1987.

Despite this body of research on hormesis, none of it was devoted to investigating the ultra-molecular doses used in some homeopathic medicines. What is interesting to note is that researchers find that the hormetic effects of small doses only seems to influence biological systems when there is repeated dosages of the noxious (or medicinal) agent, while homeopathic clinicians find that the even smaller homeopathic doses have longer lasting effects, and do not require repetition of dosages.

The Clinical Evidence

Homeopathy first became popular in Europe and the United States primarily because of the astounding successes it had in treating people during various infectious disease epidemics in the 19th century. The death rates in the homeopathic hospitals from cholera, scarlet fever, typhoid, yellow fever, pneumonia, and others was typically one-half to even one-eighth that in conventional medical hospitals.

Similarly results were also observed in mental institutions and prisons under the care of homeopathic physicians as compared to those under the care of conventional doctors.

A group of researchers at the University of Glasgow and Glasgow Homeopathic Hospital conducted four studies on people suffering from various respiratory allergies (hay fever, asthma, and perennial allergic rhinitis). In total, they treated 253 patients and found a 28% improvement in visual analogue scores in those given a homeopathic medicine, as compared with a 3% improvement in patients given a placebo. (The result was significant at P = 0.0007.).

In the hay fever study, homeopathic doses of various flowers that are known to create pollen that initiates hay fever symptoms were used, and in the other studies, the researchers conducted conventional allergy testing to assess what substance each person was most allergic to. The researchers then prescribed the 30C (100-30) of this allergic substance (House dust mite 30C was the most commonly prescribed homeopathic medicine).

The researchers called this type of prescribing “homeopathic immunotherapy,” and they conclude from their research that either homeopathic medicines work or controlled clinical trials do not.

Technically, this research may be more precisely called “isopathy” because the medicines used were not the “similar” but the “same” (“iso”) substance that was known to cause the specific symptoms of illness. However, the medicines were made in the typical homeopathic pharmacological process, and legally recognized homeopathic medicines were used in these trials.

In addition to this body of clinical evidence, an independent group of physicians and scientists evaluated clinical research prior to October, 1995. They reviewed 186 studies, 89 of which met their pre-defined criteria for their meta-analysis. They found that on average patients given a homeopathic medicine were 2.45 times more likely to have experienced a clinically beneficial effect. When reviewing only the highest quality studies and when adjusting for publication bias, the researchers found that subjects given a homeopathic medicine were still 1.86 times more likely to experience improved health as compared with those given a placebo. The researchers have also noted that it is extremely common in conventional medical research for more rigorous trials to yield less positive results than less rigorous trials.

The most important question that good scientists pose about clinical research (whether it deals with homeopathy or not) is: have there been replications of clinical studies by independent researchers?

Three separate bodies of researchers have conducted clinical trials in the use of a homeopathic medicine (Oscillococcinum 200C) in the treatment of influenza-like syndromes. Each of these trials involved relatively large numbers of subjects (487, 300, and 372), and all were multi-centered placebo-controlled and double-blinded (two of the three trials were also randomized). Each of these trials showed statistically significant results.

One other body of research in the use of Galphimia glauca in the treatment of hay fever was replicated successfully seven times, but this research was conducted by the same group of researchers, and thus far, not by any other researchers.

It would be inaccurate and biased to report only on studies that have shown positive results with homeopathic medicines. There are numerous clinical trials that have shown patients given a homeopathic medicine didn’t experience beneficial results. The meta-analysis described earlier verifies this, but it also suggests that the weight of evidence still suggests that homeopathy is more than just a placebo effect.

How does homeopathy work?

How homeopathic medicines work is presently a mystery. And yet, nature is replete with striking examples of the powerful effects of extremely small doses of active agents.

It is commonly known that certain species of moths can smell pheromones of its own species up to two miles away. Likewise, sharks are known to sense blood in the water at large distances.

I stress again that nanopharmacological doses will not have any effect unless the person is hypersensitive to the specific medicinal substance. Hypersensitivity is created when there is some type of resonance between the medicine and the person. Because the system of homeopathy bases its selection of the medicine on its ability to cause in overdose the similar symptoms that the sick person is experiencing, homeopathy’s “law of similars,” as it is called, is simply a practical method of finding the substance to which a person is hypersensitive.

The homeopathic principle of similars makes further sense when one considers that physiologists and pathologists now recognize that disease is not simply the result of breakdown or surrender of the body but that symptoms are instead representative of the body’s efforts to fight infection or adapt to stress. Fever, inflammation, pain, discharge, and even high blood pressure are but a small number of the common symptoms that the organism creates in order to defend and to try to heal itself.

Over 200 years of experience by homeopathic physicians hav found that a homeopathic medicine acts longer and deeper when it is more potentized. Although no one knows precisely why this happens, it is conjectured that highly potentized nanopharmacological doses can more deeply penetrate cells and the blood-brain barrier than less potentized medicines. Although there is no consensus on why these ultramolecular doses work more deeply, there is consensus from users of these natural medicines that they do.

One cannot help but sense the potential treasure-trove of knowledge that further research in homeopathy and nanopharmacology will bring in this new millennium.

Dana Ullman, M.P.H. has written seven books, the latest, Homeopathic Family Medicine, reviews and describes the various clinical trials using homeopathic medicines to treat common acute and chronic ailments (see http://www.homeopathic.com/). He has served as an advisor in alternative medicine institutes at Harvard, Columbia, and University of Arizona schools of medicine, and has developed the curriculum in homeopathy for the University of Arizona’s Program in Integrative Medicine.

How to choose an online drug store is trustworthy

online-drugstore

Maybe you can imitate how the American people in choosing an online drugstore. Indeed, in the international regulation of pharmacy no guarantee of security and legal certainty to these online drug stores. But at least there are some online drug store can be trusted and you just have to know how to find them. Here’s what to know to do just that.

1. What an online pharmacy is

Online pharmacies are Internet-based vendors of prescription drugs. Because they can serve a large clientele from one central location — and avoid the cost of operating brick-and-mortar branches — they can sell medications more cheaply than traditional pharmacies.

In many cases, foreign online pharmacies can sell drugs for even less than domestic ones. Price caps that many countries place on drugs help drive down the costs.

2. Not every online pharmacy is the same

There are thousands of online pharmacies. Many are legal and legitimate, but many aren’t.

In many cases, illegitimate pharmacies don’t operate in compliance with U.S. rules and regulations. These pharmacies are considered fraudulent, and most of them are based in other countries, or claim to be. For example, many popular pharmacies operate out of Mexico and India, where medications are particularly inexpensive, but these countries don’t have medication quality and security guidelines as stringent as in the U.S. and Canada.

Fraudulent pharmacies have multiple ways of deceiving consumers. Some might send a non-U.S. version of your drug, an incorrect dosage or a generic when your doctor has prescribed a brand name. In other cases, you might receive the incorrect medication or a sugar pill without any active ingredients. You might also receive a medication with an incomplete or missing label, making it difficult to tell drugs apart or how to take them.

3. What the FDA says about foreign online pharmacies

No law explicitly forbids importing prescription drugs from other countries, so long as they aren’t controlled substances and are purchased with the approval of a licensed physician. Even so, the FDA recommends against buying drugs from other countries because consumers can’t confirm their safety and have no recourse against the manufacturers.

4. What is definitely legal

It’s definitely legal to purchase drugs through a U.S.-based online pharmacy that has been certified by the National Association of Boards of Pharmacy. The association is a professional organization that supports state pharmacy boards and is recognized by the FDA as the nation’s leading pharmacy authority.

Some online pharmacies aren’t verified by the association, but are verified by independently owned LegitScript. LegitScript approves only U.S.-based online pharmacies, and is acknowledged by the boards of pharmacy association for recognizing safe practices and complying with federal law. Unlike the association, however, LegitScript doesn’t require a fee or application from pharmacies for verification.

5. What is definitely illegal

It is illegal to do the following:

– Purchase controlled substances without a prescription written by a licensed doctor. This includes all prescription narcotic painkillers, sedatives, stimulants and anabolic steroids.
– Purchase prescription drugs that aren’t FDA approved, even if they’re legal in the country from which you purchase them.

If you can want to buy from a foreign pharmacy, you’ll also be held to that country’s laws. In order to legally purchase a controlled medicine from a Mexican online pharmacy, for example, you’ll need a prescription from a licensed Mexican physician in addition to the prescription from your local doctor.

6. How Canadian online pharmacies are different

Canadian pharmacy practices and standards are similar to those in the U.S. Legitimate Canadian pharmacies don’t require a separate Canadian prescription and avoid selling controlled substances to U.S. patients in order to comply with our laws. However, the FDA reports that many online pharmacies that appear Canadian are actually operating out of other countries.

True Canadian pharmacies are certified by the Canadian International Pharmacy Association, but they can’t be verified by U.S. pharmacy bodies. Even though research has shown that legitimate Canadian pharmacies sell legitimate drugs at cheaper prices, the FDA still advises against these purchases.

7. What the research says about online pharmacies

Two major studies have assessed online pharmacies. The most recent, conducted by the boards of pharmacy association in September 2013, found that 96.7% of online pharmacies selling to U.S. citizens were “rogue,” meaning that they didn’t comply with U.S. laws and regulations. The report covered 10,642 pharmacies, and determined that only 90 were legitimate, while another 258 were classified as potentially legitimate.

The National Bureau of Economic Research did a more comprehensive study in 2012. To assess drug cost and integrity, researchers acquired samples of the most popular dosages of five common brand name prescription drugs  — Lipitor, Viagra, Celebrex, Nexium and Zoloft — from a variety of online pharmacies. Researchers concluded that:

– All of the U.S. pharmacies required a process that ensures the prescription is authentic, compared with 90% of Canadian pharmacies and 67% of foreign pharmacies.
– 10% of the drugs provided were incorrect, or generic when a name brand was prescribed.
– Although there are many rogue pharmacies online, a blanket ban against certified Canadian pharmacies is unjustified and would prevent considerable savings for consumers, since Canadian drugs are 49% cheaper than those bought in the U.S.

8. Guidelines for safely purchasing drugs online

Use these guidelines to ensure your safety and the security of your personal information when buying medications online:

– Look for pharmacies that are certified by the U.S. or Canadian pharmacy association, indicating that they follow stringent safety and quality standards.
– Cross-check your pharmacy’s certification against the associations’ websites.
– Don’t buy from websites that sell drugs without a prescription, or that offer to prescribe the drug for you.
– Make sure your online pharmacy’s privacy and security policies are easy to understand. Illegal pharmacies will often sell your personal information.
– Check your pharmacy’s website for a physical address and a phone number you can call to talk to a pharmacist.
– Ask for your pharmacist’s license information. If he or she is U.S.-based, you can verify this information online.

Use the links below for more specific information.

– The National Association of Boards of Pharmacy has a listing of recommended sites ( http://www.nabp.net/programs/consumer-protection/buying-medicine-online/recommended-sites ).
– The association’s not recommended sites are ( http://www.nabp.net/programs/consumer-protection/buying-medicine-online/not-recommended-sites ).
– LegitScript’s recommended sites are ( http://www.legitscript.com/pharmacies ).
– If you’re looking into Canadian pharmacies, verify Canadian International Pharmacy Association certification ( http://www.cipa.com/ ).
– To find a site recommended by the Canadian association, go ( http://www.cipa.com/about/#about-member-list-section ).
– PharmacyChecker’s reviews are ( http://www.pharmacychecker.com/online-pharmacy-ratings.asp ).

Source : www.nerdwallet.com

Natural therapy for a woman is experiencing hot flashes

hot-flashes

Hot flashes vary among women going through menopause. Some women have hot flashes for a very short time during menopause. Other women may have hot flashes for life. Generally, hot flashes are less severe as time passes. You may not be able to avoid hot flashes during menopause, try eating or doing natural therapy below might relieve yourself.

Black Cohosh
(Actaea racemosa, Cimicifuga racemosa) This herb has received quite a bit of scientific attention for its possible effects on hot flashes. Studies of its effectiveness in reducing hot flashes have produced mixed results. However, some women report that it has helped them. Recent research suggests that black cohosh does not act like estrogen, as once thought. This reduces concerns about its effect on hormone-sensitive tissue (eg, uterus, breast). Black cohosh has had a good safety record over a number of years. There have been reports linking black cohosh to liver problems, and this connection continues to be studied.

Red Clover
(Trifolium pratense) In five controlled studies, no consistent or conclusive evidence was found that red clover leaf extract reduces hot flashes. As with black cohosh, however, some women claim that red clover has helped them. Studies report few side effects and no serious health problems with use. But studies in animals have raised concerns that red clover might have harmful effects on hormone-sensitive tissue.

Dong Quai
(Angelica sinensis) Dong quai has been used in Traditional Chinese Medicine to treat gynecologic conditions for more than 1,200 years. Yet only one randomized clinical study of dong quai has been conducted to determine its effects on hot flashes, and this botanical therapy was not found to be useful in reducing them. Some experts on Chinese medicine point out that the preparation studied was not the same as they use in practice. Dong quai should never be used by women with fibroids or blood-clotting problems such as hemophilia, or by women taking drugs that affect clotting such as warfarin (Coumadin) as bleeding complications can result.

Ginseng
(Panax ginseng or Panax quinquefolius) Research has shown that ginseng may help with some menopausal symptoms, such as mood symptoms and sleep disturbances, and with one’s overall sense of well-being. However, it has not been found to be helpful for hot flashes.

Kava
(Piper methysticum) Kava may decrease anxiety, but there is no evidence that it decreases hot flashes. It is important to note that kava has been associated with liver disease. The FDA has issued a warning to patients and providers about kava because of its potential to damage the liver. Because of this concern, Health Canada does not allow kava to be sold in Canada.

Evening Primrose Oil
(Oenothera biennis) This botanical is also promoted to relieve hot flashes. However, the only randomized, placebo-controlled study (in only 56 women) found no benefit over placebo (mock medication). Reported side effects include inflammation, problems with blood clotting and the immune system, nausea, and diarrhea. It has been shown to induce seizures in patients diagnosed with schizophrenia who are taking antipsychotic medication. Evening primrose oil should not be used with anticoagulants or phenothiazines (a type of psychotherapeutic agent).

Use with Caution
Of course, as with all therapies, there are some risks involved. The public usually takes herbal therapies in the form of supplement pills, not as a preparation made directly from the herb by a trained herbalist. Keep in mind that herbal supplements are not as closely regulated as prescription drugs. The amount of herbal product, quality, safety, and purity may vary between brands or even between batches of the same brand. Herbal therapies may also interact with prescription dugs, resulting in dramatic changes in the effect of the botanical, the drug, or both. To be safe, tell your healthcare provider about all botanical therapies you are considering and always stop all herbal treatments at least 2 weeks before any planned surgery.

Source : http://www.menopause.org